Leonidas Bleris - Center for Systems Biology

Leonidas Bleris

FAS Center for Systems Biology
Harvard University
7 Divinity Ave
Cambridge, MA 02138, USA

Tel: 617-498-3865
Fax: 617-495-2196
E-mail: lbleris at cgr dot harvard dot edu

I am an Assistant Professor with the Electrical Engineering Department of the University of Texas at Dallas and a visiting scientist with the Laboratory for Molecular Automata at the FAS Center for Systems Biology.

News/Media:

Journal publications:

Vouzis, P. D., L. G. Bleris, M. G. Arnold, M. V. Kothare. A System-on-a-Chip Implementation for Embedded Real-Time Model Predictive Control. IEEE Transactions on Control Systems Technology, 17:5, 1006-1017, 2009.
L. G. Bleris. Molecular Circuits for Information Processing in Human Cells. Bio 24, 42-46, 2008 (Invited article)
Rinaudo, K.*, L. G. Bleris*, R. Maddamsetti, S. Subramanian, R. Weiss, Y. Benenson. A universal RNAi-based logic evaluator that operates in mammalian cells. Nature Biotechnology 25, 795-801, 2007 (*equal contribution)
Bleris, L. G., P. D. Vouzis, J. G. Garcia, M. G. Arnold, M. V. Kothare. Pathways for Optimization-based Drug Delivery Systems and Devices. Control Engineering Practice, Volume 15, Issue 10, October 2007, Pages 1280-1291
Bleris, L. G., J. G. Garcia, M. G. Arnold., M. V. Kothare. Model Predictive Hydrodynamic Regulation of Microflows. Journal of Micromechanics and Microengineering, 16, 1792-1799, 2006.
Bleris, L. G., J. G. Garcia, M. V. Kothare, M. G. Arnold. Towards Embedded Model Predictive Control for System-On-a-Chip Applications. Journal of Process Control, 16, 255-264, Mar. 2006.
Bleris, L. G. and M. V. Kothare. Reduced Order Distributed Boundary Control of Thermal Transients in Microsystems. IEEE Transactions on Control Systems Technology, 13:6, 853-867, 2005.
Bleris, L. G. and M. V. Kothare. Low-Order Empirical Modeling of Distributed Parameter Systems Using Temporal and Spatial Eigenfunctions. Computers & Chemical Engineering, 29, 817-827, 2005.

Selected Presentations/Conference Proceedings:

Bleris, L. G., K. Rinaudo, R. Maddamsetti, S. Subramanian, R. Weiss, Y. Benenson. Design and Optimization of an RNAi Based Biomolecular Logic Circuit. AIChE annual meeting, Philadelphia, PA, November 2008.
Bleris, L. G., K. Rinaudo, R. Maddamsetti, S. Subramanian, R. Weiss, Y. Benenson. A Universal Logic Evaluator that Operates in Mammalian Cells. 4th International Greek Biotechnology Forum, Athens, Greece, May 2008.
Bleris, L. G., K. Rinaudo, R. Maddamsetti, S. Subramanian, R. Weiss, Y. Benenson. An in Vivo General Purpose Molecular Logic Evaluator. AIChE annual meeting, Salt Lake City, UT, November 2007.
Bleris, L. G. Creating logic circuits using RNAi. Meeting of the National Centers of Integrative and Systems Biology, Boston, MA, June 2007.
Bleris, L. G., P. D. Vouzis, M. G. Arnold, M. V. Kothare. A Co-Processor FPGA Platform for the Implementation of Real-Time Model Predictive Control. American Control Conference 2006, Minneapolis, Minnesota, July 2006.
Bleris, L. G. and M. V. Kothare. Implementation of Model Predictive Control for Glucose Regulation using a General Purpose Microprocessor. 44th IEEE Conference on Decision and Control and European Control Conference ECC 2005, Seville (Spain), December 2005.
Bleris, L. G. and M. V. Kothare. Entropy of Spatiotemporal Data as a Dynamic Truncation Indicator for Model Reduction Applications. American Control Conference, Pages: 3145-3150, Portland, OR, June 2005. (Best Presentation in Session Award)
Bleris, L. G., Kothare, M. V., Garcia, J. and M. G. Arnold. Embedded Model Predictive Control for System-On-a-Chip Applications. 7th International Symposium on Dynamics and Control of Process Systems, Boston, MA, July 2004.
Bleris, L. G. and M. V. Kothare. Finite Element Method Simulations of Microchannels for Control and Reduced Order Modeling Applications. Proceedings of Mathematics and Informatics for Industry Conference, Pages: 162-169 Thessaloniki, Greece, April 2003.