MacBeath Lab Publications

Research

Chen JR, Chang BH, Allen JE, Stiffler MA, & MacBeath G (2008). Predicting PDZ Domain–Peptide Interactions from Primary Sequences. Nat. Biotechnol., in press.

Kaushansky A, Gordus A, Budnik BA, Lane WS, Rush J, & MacBeath G (2008). System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chem. Biol., in press.

Kaushansky A, Gordus A, Chang B, Rush J, & MacBeath G (2008). A quantitative study of the recruitment potential of all intracellular tyrosine residues on EGFR, FGFR1 and IGF1R. Mol. BioSyst. 4: 643-653. abstract

Stiffler MA, Chen JR, Grantcharova VP, Lei Y, Fuchs D, Allen JE, Zaslavskaia LA, MacBeath G (2007). PDZ domain binding selectivity is optimized across the mouse proteome. Science 317: 364-369. abstract full text

Gordus A & MacBeath G (2006). Circumventing the problems caused by protein diversity in microarrays: implications for protein interaction networks. J. Am. Chem. Soc. 128: 13668-13669. abstract

Sevecka M & MacBeath G (2006). State-based discovery: a multidimensional screen for small molecule modulators of EGF signaling. Nat. Methods 3: 825-831. abstract

Stiffler MA, Grantcharova VP, Sevecka M, & MacBeath G (2006). Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays. J. Am. Chem. Soc. 128: 5913-5922. abstract

Jones RB, Gordus A, Krall JA, MacBeath G (2006). A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature 439: 168-174; advance online publication, 6 November 2005 (doi:10.1038/nature04177). abstract

Nielsen UB, Cardone MH, Sinskey AJ, MacBeath G, & Sorger PK (2003). Profiling receptor tyrosine kinase activation by using Ab microarrays. Proc. Natl. Acad. Sci. USA 100: 9330-9335. abstract full text

MacBeath G & Schreiber SL (2000). Printing proteins as microarrays for high throughput function determination. Science 289(5485): 1760-1763. abstract

Reviews, Opinions, Commentaries, and Protocols

Albeck JG, MacBeath G, White FM, Sorger PK, Lauffenburger DA, & Gaudet S (2006). Collecting and organizing systematic sets of protein data. Nature Reviews | Molecular Cell Biology 7: 803-812. abstract

MacBeath G (2002). Protein microarrays and proteomics. Nature Genetics 32 Suppl 2: 526-532. abstract

MacBeath G (2002). Protein microarrays facilitate the large-scale study of proteins; and Protocols 10-14.  In Proteins and Proteomics: A Laboratory Manual (Richard Simpson), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp 691-700, 772-786.

MacBeath G (2001). Proteomics comes to the surface. Nature Biotechnology 19(9): 828-829.

MacBeath G (2001). Chemical genomics: What will it take and who gets to play? Genome Biology 2(6): 2005.1-2005.6. abstract full text

Pre-MacBeath Lab Publications

Research

MacBeath G, Koehler AN, & Schreiber SL (1999). Printing small molecules as microarrays and detecting protein-ligand interactions en masse. J. Am. Chem. Soc. 121: 7967-7968.

MacBeath G, Kast P, & Hilvert D (1998). Redesigning enzyme topology by directed evolution. Science 279(5358): 1958-1961. abstract

MacBeath G, Kast P, & Hilvert D (1998). A small, thermostable, and monofunctional chorismate mutase from the archeon Methanococcus jannaschii. Biochemistry 37(28): 10062-10073. abstract

MacBeath G, Kast P, & Hilvert D (1998). Probing enzyme quaternary structure by combinatorial mutagenesis and selection. Protein Science 7: 1757-1767. abstract full text

MacBeath G & Kast P (1998). UGA read-through artifacts – when popular gene expression systems need a pATCH. BioTechniques 24(5) : 789-794. abstract

MacBeath G, Kast P, & Hilvert D (1998). Exploring sequence constraints on an interhelical turn using in vivoselection for catalytic activity. Protein Science 7(2): 325-335. abstract full text

MacBeath G & Hilvert D (1994). Monitoring catalytic activity by immunoassay: implications for screening. J. Am. Chem. Soc. 116: 6101-6106.

LéJohn HB, Cameron LE, Yang B, MacBeath G, Barker DS & Williams SA (1994). Cloning and analysis of a constitutive heat shock (cognate) protein 70 gene inducible by L-glutamine. J. Biol. Chem. 269(6): 4513-4522. abstract full text

Reviews, Opinions, Commentaries, and Protocols

Hilvert D, Shin J, & MacBeath G (1998). The Structural Basis of Antibody Catalysis. In Peptides and Proteins. (S.M. Hecht, ed), Oxford University Press, New York, pp. 335-366.

MacBeath G & Hilvert D (1996). Hydrolytic antibodies: variations on a theme. Chemistry & Biology 3(6): 433-445. abstract